Half-life actually refers to how long it takes for half the drug to be eliminated from the plasma of the blood. Half-life is one of those medical terms many people use but few understand, often thought to be how long half of the medicine remains in the system as a whole. This data is based on two placebo-controlled classroom studies conducted in ADHD children of ages 6 to 12 years. To answer the question “How long does Vyvanse take to kick in?”, it becomes significantly effective 1.5 to 2 hours following oral administration. It is quickly absorbed from the gastrointestinal tract after oral administration, and as mentioned earlier, is then converted into Dextroamphetamine, a drug with a plasma elimination half-life of about 12 hours. Lisdexamfetamine dimesylate has a typical plasma elimination half-life of less than an hour on average. What this means is that Vyvanse (Lisdexamfetamine dimesylate) is converted to Dextroamphetamine (d-amphetamine), its active component, when it is absorbed in the body. This medication is a pro-drug of dextroamphetamine (d-amphetamine). To add to that, one may experience increased heart rate and blood pressure, serious cardiovascular reactions, psychiatric adverse reactions such as psychotic or manic symptoms, and serotonin syndrome. Furthermore, without a doctor’s supervision, there is an increased risk for dependence, abuse, or addiction. Among Vyvanse side effects sexual adverse reactions are also common. The potential loss of or decrease in appetite may lead to weight loss, and although Vyvanse for weight loss has no approval, some may use it for that purpose without a doctor’s prescription, which is dangerous. Lisdexamfetamine dimesylate has similar side effects with other stimulant drugs used for the treatment of ADHD, which include dry mouth, anxiety, trouble sleeping, nausea, vomiting, and loss of or decreased appetite, among others. What is known is that it promotes and increases the release of dopamine and norepinephrine into the extraneuronal space to reduce the symptoms of ADHD in patients with the said disorder. However, how it exactly acts therapeutically in ADHD and BED patients is not currently known. ![]() Lisdexamfetamine dimesylate is a stimulant medication that directly acts on the central nervous system (CNS). That is why this drug is a quintessential example of a “ pro-drug.” Its effects become noticeable at the 1.5 or 2-hour mark, which is a bit slower compared to Adderall. Its basic component, Lisdexamfetamine dimesylate, becomes active only after absorption and conversion into d-amphetamine, its active ingredient. The drug Vyvanse is used for the treatment of ADHD and binge-eating disorder (BED). ![]() How Does Lisdexamfetamine Dimesylate Work? People who are worried about how long Vyvanse remains in the system need to know about the variables that can influence this to avoid overdose or other complications.
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